发明申请
- 专利标题: INTRANASAL SPRAY DEVICE CONTAINING PHARMACEUTICAL COMPOSITION
- 专利标题(中): 包含药物组合物的内窥镜喷雾装置
-
申请号: US13541325申请日: 2012-07-03
-
公开(公告)号: US20120270903A1公开(公告)日: 2012-10-25
- 发明人: Peter James WATTS , Jonathan David CASTILE , William Columbus Ian LAFFERTY , Alan SMITH
- 申请人: Peter James WATTS , Jonathan David CASTILE , William Columbus Ian LAFFERTY , Alan SMITH
- 申请人地址: GB Nottingham
- 专利权人: ARCHIMEDES DEVELOPMENT LIMITED
- 当前专利权人: ARCHIMEDES DEVELOPMENT LIMITED
- 当前专利权人地址: GB Nottingham
- 优先权: GB0300531.1 20030110
- 主分类号: A61K31/4468
- IPC分类号: A61K31/4468 ; A61M11/00
摘要:
An intranasnal spray device contains a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
公开/授权文献
信息查询
IPC分类: