发明申请
- 专利标题： Antibody Glycosylation Variants
- 专利标题（中）： 抗体糖基化变体
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申请号： US13504803申请日： 2010-10-25
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公开(公告)号： US20120276092A1公开(公告)日： 2012-11-01
- 发明人: Jinquan Luo , Stephen McCarthy , T. Shantha Raju , Bernard Scallon , Tracy Spinka-Doms
- 申请人： Jinquan Luo , Stephen McCarthy , T. Shantha Raju , Bernard Scallon , Tracy Spinka-Doms
- 国际申请： PCT/US10/53948 WO 20101025
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; A61K39/395 ; C07K19/00
摘要：
Antibody and other Fc-containing molecules with glycosylation variations in the Fc region show increased resistance to proteases, such as pepsin, plasmin, trypsin, chymotrypsin, a matrix metalloproteinase, a serine endopeptidase, and a cysteine protease. The Fc-containing molecules are useful in the treatment of various diseases and disorders.
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