发明申请
- 专利标题： VACCINE VECTORS AND METHODS OF ENHANCING IMMUNE RESPONSES
- 专利标题（中）： 疫苗载体和增强免疫应答的方法
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申请号： US13574504申请日： 2011-01-21
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公开(公告)号： US20120282291A1公开(公告)日： 2012-11-08
- 发明人: Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
- 申请人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
- 申请人地址： US AR Little Rock US TX College Station
- 专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,THE TEXAS A&M UNIVERSITY SYSTEM
- 当前专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,THE TEXAS A&M UNIVERSITY SYSTEM
- 当前专利权人地址： US AR Little Rock US TX College Station
- 国际申请： PCT/US11/22062 WO 20110121
- 主分类号： A61K39/145
- IPC分类号： A61K39/145 ; A61P31/16 ; C12N1/21
摘要：
Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
公开/授权文献
- US08956618B2 Vaccine vectors and methods of enhancing immune responses 公开/授权日：2015-02-17