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公开(公告)号：US08956849B2
公开(公告)日：2015-02-17
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： C07H21/04 , C07H21/02 , C12N7/00 , C12N7/01 , C12N15/00 , C07K14/705 , C07K14/455 , A61K39/00
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。 疫苗还可以包括能够结合CD40的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
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公开(公告)号：US20110027309A1
公开(公告)日：2011-02-03
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/00 , C12N15/63 , A61K39/02 , A61K39/145 , A61K39/112 , C12N1/21 , C12N15/64 , A61P37/04 , A61P31/16
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译： 本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。 还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。 还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。 公开了开发细菌疫苗载体的方法。 还公开了在细菌中产生无疤痕位点突变的方法。
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公开(公告)号：US08956618B2
公开(公告)日：2015-02-17
申请号：US13574504
申请日：2011-01-21
申请人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
发明人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
IPC分类号： A61K49/00 , A61K39/00 , A61K39/12 , A61K39/385 , A61K39/145 , A61K39/02 , A61K45/00 , C12Q1/68
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
摘要翻译： 本文提供疫苗载体，其包含存在于疫苗载体表面上的抗原性多肽和HMGB1多肽。 还提供了包含疫苗载体的组合物，并且包括药学上可接受的载体，适合用于口服或鼻给药的载体。 还提供了通过将本文公开的疫苗载体或组合物施用于受试者来增强免疫应答，特别是抗体免疫应答和适当地IgA应答的方法。
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公开(公告)号：US20110111015A1
公开(公告)日：2011-05-12
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： A61K9/127 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/112 , A61K39/07 , A61K39/108 , A61K39/002 , A61K39/012 , A61K39/015 , A61P37/04 , A61P33/02
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。 疫苗还可以包括能够结合CD4Q的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
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公开(公告)号：US08604178B2
公开(公告)日：2013-12-10
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： C07H21/02 , A61K49/00 , A61K39/112
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译： 本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。 还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。 还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。 公开了开发细菌疫苗载体的方法。 还公开了在细菌中产生无疤痕位点突变的方法。
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6.发明授权Compositions and methods of enhancing immune responses to flagellated bacterium 有权增强对鞭毛细菌的免疫应答的组合物和方法公开(公告)号：US09125854B2
公开(公告)日：2015-09-08
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/02 , A61K39/112 , A61K39/00
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译： 提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。 还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。
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公开(公告)号：US20120282291A1
公开(公告)日：2012-11-08
申请号：US13574504
申请日：2011-01-21
申请人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
发明人： Luc Berghman , Walter Bottje , Billy Hargis , Sherryll Layton
IPC分类号： A61K39/145 , A61P31/16 , C12N1/21
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
摘要翻译： 本文提供疫苗载体，其包含存在于疫苗载体表面上的抗原性多肽和HMGB1多肽。 还提供了包含疫苗载体的组合物，并且包括药学上可接受的载体，适合用于口服或鼻给药的载体。 还提供了通过将本文公开的疫苗载体或组合物施用于受试者来增强免疫应答，特别是抗体免疫应答和适当地IgA应答的方法。
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8.发明申请COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM 有权增强对细菌细菌的免疫反应的组合物和方法公开(公告)号：US20110159026A1
公开(公告)日：2011-06-30
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/112 , A61P37/04 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译： 提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。 还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。
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公开(公告)号：US20100120016A1
公开(公告)日：2010-05-13
申请号：US12439462
申请日：2007-08-31
申请人： Yanbin Li , Billy Hargis , Steve Tung , Luc Berghman , Walter Bottje , Ronghui Wang , Zunzhong Ye , Madhukar Varshney , Balaji Srinivasan
发明人： Yanbin Li , Billy Hargis , Steve Tung , Luc Berghman , Walter Bottje , Ronghui Wang , Zunzhong Ye , Madhukar Varshney , Balaji Srinivasan
IPC分类号： C12Q1/70
摘要： An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer supported by the housing and operable to measure impedance of the starting material to detect the presence of a contaminant.
摘要翻译： 一种用于检测起始材料中的污染物的阻抗生物传感器，所述生物传感器包括壳体，由壳体支撑的输入装置，由壳体支撑的输出装置，由壳体支撑的微流体单元，起始材料可与微流体接合 电池和由壳体支撑的阻抗分析仪，并可操作以测量起始材料的阻抗以检测污染物的存在。
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10.发明申请COMPOSITIONS AND METHODS FOR INCREASING POULTRY HATCHABILITY AND EARLY PERFORMANCE 审中-公开组合物和方法可以提高预防性和早期性能公开(公告)号：US20130116174A1
公开(公告)日：2013-05-09
申请号：US13809450
申请日：2011-07-11
申请人： Billy Hargis , Walter Bottje
发明人： Billy Hargis , Walter Bottje
IPC分类号： A61K38/17 , A61K31/718
CPC分类号： A61K38/1703 , A01K45/007 , A61K31/718 , C08L3/02 , C08L89/00 , C08L89/005
摘要： Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch. The compositions include iodinated tyrosine-containing proteins, suitably iodinated casein, and carbohydrates.
摘要翻译： 本文提供了改善家禽孵化器健康的组合物和方法。 孵化前可以通过在卵内施用组合物来改善家禽孵化的健康和孵化率。 组合物包括含碘化酪氨酸的蛋白质，合适的碘化酪蛋白和碳水化合物。
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