发明申请
- 专利标题： SCREENING METHOD
- 专利标题（中）： 筛选方法
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申请号： US13498840申请日： 2010-09-28
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公开(公告)号： US20120283120A1公开(公告)日： 2012-11-08
- 发明人: Tatsuya Watanabe , Kazuhide Nakayama , Daisuke Nakata , Masami Kusaka
- 申请人： Tatsuya Watanabe , Kazuhide Nakayama , Daisuke Nakata , Masami Kusaka
- 申请人地址： JP Osaka
- 专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人地址： JP Osaka
- 优先权： JP2009-225541 20090929
- 国际申请： PCT/JP2010/066874 WO 20100928
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C40B30/04 ; C12N5/10 ; C12N15/113 ; C12Q1/02 ; C07H21/04 ; C12Q1/68 ; C12N15/12
摘要：
The present invention provides a novel variant androgen receptor (ARaiv) lacking ligand binding domain, a nucleic acid encoding the same and use thereof. That is, the present invention provides a method of screening for a substance for the prophylaxis or treatment of cancer, which includes contacting an ARaiv protein or ARaiv-producing cell with a test compound, measuring the activity of ARaiv (e.g., transcription regulating action of androgen responsive gene) or expression level thereof, and selecting a compound that suppresses the activity or expression level.
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