A liquid crystal display having adaptive driving mechanism includes plural pixel array areas and a driving module. Each pixel array area has a plurality of pixels. The driving module includes a signal generation unit for generating grey-level signals corresponding to the pixels based on input image data, a weighting conversion unit for converting the grey-level signals corresponding to the pixels into a plurality of weightings, a weighting processing unit for generating a weighting sum by summing up the weightings corresponding to the pixel array area, an inversion-mode setting unit for setting a polarity inversion mode according to the weighting sum, and a data signal output unit. The data signal output unit is utilized for providing a plurality of data signals to be written into the pixel array area based on the polarity inversion mode.