发明申请
- 专利标题: Method Of Reducing Injury To Mammalian Cells
- 专利标题(中): 减少哺乳动物细胞损伤的方法
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申请号: US13286071申请日: 2011-10-31
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公开(公告)号: US20120302504A1公开(公告)日: 2012-11-29
- 发明人: Michael Tymianski
- 申请人: Michael Tymianski
- 申请人地址: CA TORONTO
- 专利权人: NONO, INC.
- 当前专利权人: NONO, INC.
- 当前专利权人地址: CA TORONTO
- 优先权: CA2273622 19990602
- 主分类号: A61K38/08
- IPC分类号: A61K38/08 ; A61P9/10 ; A61P25/00
摘要:
A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor-neuronal protein interaction. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity, ischemic and traumatic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95/NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults, dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia, and traumatic brain injury (TBI) in rats.
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