发明申请
- 专利标题： OLIGONUCLEOTIDES WHICH INHIBIT P53 INDUCTION IN RESPONSE TO CELLULAR STRESS
- 专利标题（中）： 抑制P53诱导细胞应激反应的寡核苷酸
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申请号： US13575492申请日： 2011-01-28
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公开(公告)号： US20120302628A1公开(公告)日： 2012-11-29
- 发明人: Michael B. Kastan , Jing Chen
- 申请人： Michael B. Kastan , Jing Chen
- 申请人地址： US TN Memphis
- 专利权人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- 当前专利权人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- 当前专利权人地址： US TN Memphis
- 国际申请： PCT/US11/22930 WO 20110128
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C12N5/071 ; C07H21/04
摘要：
The present invention relates to novel oligonucleotides which comprise p53 5′-UTR sequence TCCCTGG (SEQ ID NO: 1) or the complementary p53 3′-UTR sequence CCAGGGA (SEQ ID NO: 2) and their use for such therapeutic applications as protection of normal tissues from the toxicities of chemical or radiation exposure; reducing tissue damage in hypoxia-reperfusion injury, neurodegenerative disorders, oxidative stress, injuries, hyperthermia; preventing aging; preservation of tissues and organs prior to transplanting, etc.