发明申请
- 专利标题: HIGHLY PERMEATING TERBINAFINE FORMULATION
- 专利标题(中): 高效透皮贴剂配方
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申请号: US13525108申请日: 2012-06-15
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公开(公告)号: US20120309843A1公开(公告)日: 2012-12-06
- 发明人: Servet Buyuktimkin , Nadir Buyuktimkin , Jagat Singh , John M. Newsam , Dominic King-Smith , Edward Kisak
- 申请人: Servet Buyuktimkin , Nadir Buyuktimkin , Jagat Singh , John M. Newsam , Dominic King-Smith , Edward Kisak
- 申请人地址: CA Mississauga
- 专利权人: Nuvo Research Inc.
- 当前专利权人: Nuvo Research Inc.
- 当前专利权人地址: CA Mississauga
- 主分类号: A61K31/137
- IPC分类号: A61K31/137 ; A61P31/10
摘要:
The present invention provides topical compositions, methods of preparation, and methods of treatment for onychomychosis. In certain specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a zwitterionic surfactant or charged derivative thereof; a carboxylic acid, a lower alcohol, and water. The acid is selected from a short-chain hydroxy acid, a short-chain fatty acid, and a mixture thereof. In certain other specific embodiments, the invention provides an anti-fungal pharmaceutical composition for topical application comprising an anti-fungal agent, a quarternary amino acid, a keratolytic agent; a lower alcohol; and water. In certain embodiments, the keratolytic agent is urea, ammonium thioglycolate, or a mixture thereof.
公开/授权文献
- US09084754B2 Highly permeating terbinafine formulation 公开/授权日:2015-07-21