发明申请
- 专利标题： MACROCYCLES AS FACTOR XIA INHIBITORS
- 专利标题（中）： MACROCYCLES作为因子XIA抑制剂
-
申请号： US13577666申请日： 2011-02-10
-
公开(公告)号： US20120309960A1公开(公告)日： 2012-12-06
- 发明人: Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
- 申请人： Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
- 专利权人： Bristol-Meyers Squibb Company
- 当前专利权人： Bristol-Meyers Squibb Company
- 国际申请： PCT/US11/24308 WO 20110210
- 主分类号： C07D498/06
- IPC分类号： C07D498/06 ; C07D471/16 ; C07D471/06 ; C07D487/06 ; C07D487/16
摘要：
The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
公开/授权文献
- US08828983B2 Macrocycles as factor XIa inhibitors 公开/授权日：2014-09-09
信息查询
