Invention Application
- Patent Title: ANTI-C4.4A ANTIBODIES AND USES THEREOF
- Patent Title (中): 抗C4.4A抗体及其用途
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Application No.: US13514789Application Date: 2010-12-08
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Publication No.: US20120321619A1Publication Date: 2012-12-20
- Inventor: Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
- Applicant: Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
- Applicant Address: DE Monheim
- Assignee: BAYER INTELLECTUAL PROPERTY GMBH
- Current Assignee: BAYER INTELLECTUAL PROPERTY GMBH
- Current Assignee Address: DE Monheim
- Priority: EP09178474.4 20091209; EP10170797.4 20100726
- International Application: PCT/EP2010/069216 WO 20101208
- Main IPC: C07K16/30
- IPC: C07K16/30 ; C12N15/85 ; A61P35/04 ; C12P21/08 ; A61K39/395 ; C12N1/21 ; C12N15/13 ; C12N5/10
Abstract:
The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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