发明申请
- 专利标题： ANTI-C4.4A ANTIBODIES AND USES THEREOF
- 专利标题（中）： 抗C4.4A抗体及其用途
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申请号： US13514789申请日： 2010-12-08
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公开(公告)号： US20120321619A1公开(公告)日： 2012-12-20
- 发明人: Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
- 申请人： Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
- 申请人地址： DE Monheim
- 专利权人： BAYER INTELLECTUAL PROPERTY GMBH
- 当前专利权人： BAYER INTELLECTUAL PROPERTY GMBH
- 当前专利权人地址： DE Monheim
- 优先权： EP09178474.4 20091209; EP10170797.4 20100726
- 国际申请： PCT/EP2010/069216 WO 20101208
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; C12N15/85 ; A61P35/04 ; C12P21/08 ; A61K39/395 ; C12N1/21 ; C12N15/13 ; C12N5/10
摘要：
The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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