Invention Application
US20120322819A1 COMPOUND CONTAINING A NOVEL 4-ALKOXYPYRIMIDINE STRUCTURE AND MEDICINE CONTAINING SAME
审中-公开
含有新型4-烷氧基嘧啶结构的化合物和含有其的药物
- Patent Title: COMPOUND CONTAINING A NOVEL 4-ALKOXYPYRIMIDINE STRUCTURE AND MEDICINE CONTAINING SAME
- Patent Title (中): 含有新型4-烷氧基嘧啶结构的化合物和含有其的药物
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Application No.: US13580056Application Date: 2011-02-25
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Publication No.: US20120322819A1Publication Date: 2012-12-20
- Inventor: Toru Miura , Kazuhiro Onogi , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
- Applicant: Toru Miura , Kazuhiro Onogi , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
- Applicant Address: JP Nagoya-shi, Aichi
- Assignee: KOWA COMPANY, LTD.
- Current Assignee: KOWA COMPANY, LTD.
- Current Assignee Address: JP Nagoya-shi, Aichi
- Priority: JP2010-040474 20100225
- International Application: PCT/JP2011/001086 WO 20110225
- Main IPC: A61K31/506
- IPC: A61K31/506 ; C07D413/14 ; A61P9/00 ; A61P3/04 ; A61P9/10 ; A61P3/00 ; A61P3/10 ; C07D413/10 ; A61P9/12

Abstract:
Disclosed is novel compound and medicinal formulation containing same, possessing both angiotensin II receptor blocking and PPARγ activation effect, of use as a medicine for prevention and/or treatment of hypertension, heart disease, angina pectoris, cerebrovascular disorder, cerebral circulatory disturbances, post-ischemic peripheral circulatory damage, renal disease, arteriosclerosis, inflammatory disorder, type 2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinaemia. Further disclosed is the general formula I (where one or both of R1 and R2 represent a C1-6 alkyl group, R3 represents a C1-6 alkyl group which may contain one or more substituent groups selected from group A, or a C3-8 cycloalkyl group which may contain one or more substituent groups selected from group B.) which represents the compound, and salts thereof, solvates thereof, and medicinal compositions containing any of these.
Information query
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