A dynamically reconfigurable electrical interface is disclosed that can be used in various applications, including avionics communications. In one embodiment, a first switch receives an input signal and routes it to the applicable signal conditioning path unit that conditions the input signal, after which a second switch routes it to an amplifier. The amplifier provides an amplified signal to an analog-to-digital converter that generates a corresponding numerical value based on the voltage of the amplified signal that is analyzed by a processor to determine information conveyed by the input signal based on a particular electrical interface. Multiple distinct interfaces can be accommodated by on one more processors accessing instructions sets for processing information corresponding to a particular electrical interface. In another embodiment, the processor provides numerical values to a digital-to-analog converter producing an analog signal that is amplified, routed, and conditioned to convey information using a particular electrical interface.