发明申请
- 专利标题： METHODS OF IDENTIFYING OBM MODULATORS
- 专利标题（中）： 识别OBM调制器的方法
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申请号： US13587791申请日： 2012-08-16
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公开(公告)号： US20120329671A1公开(公告)日： 2012-12-27
- 发明人: Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
- 申请人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 优先权： JP97808/1997 19970415; JP151434/1997 19970609; JP217897/1997 19970812; JP224803/1997 19970821; JP332241/1997 19971202
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N23/00 ; G01N33/577 ; C40B30/04
摘要：
Novel proteins and polypeptides binding to osteoclastogenesis inhibitory factor (OCIF) (OCIF-binding molecules, OBMs) and nucleic acids encoding these proteins and polypeptides are provided. Processes for producing these proteins, polypeptides, and nucleic acid molecules by genetic engineering are provided. Medicinal compounds are provided which comprise proteins and nucleic acids according to the invention, as well as proteins which bind to OBM, including anti-OBM antibodies. These compounds may be used for the treatment of bone disease.
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