发明申请
- 专利标题： SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
- 专利标题（中）： 取代的吡咯并吡唑衍生物作为激酶抑制剂
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申请号： US13614499申请日： 2012-09-13
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公开(公告)号： US20130017170A1公开(公告)日： 2013-01-17
- 发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
- 申请人： Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
- 申请人地址： IT Nerviano (MI)
- 专利权人： NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人： NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人地址： IT Nerviano (MI)
- 主分类号： A61K31/4162
- IPC分类号： A61K31/4162 ; A61K31/496 ; A61K31/454 ; A61K31/5377 ; C40B40/04 ; A61P35/00 ; A61P37/00 ; A61P9/00 ; A61P31/00 ; C07D487/04 ; A61K38/21
摘要：
Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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