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公开(公告)号:US08481585B2
公开(公告)日:2013-07-09
申请号:US13614499
申请日:2012-09-13
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/4162 , A61K31/454 , C07D487/02 , C07D401/14
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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公开(公告)号:US20130344031A1
公开(公告)日:2013-12-26
申请号:US14010819
申请日:2013-08-27
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: C07D487/04 , A61K31/454 , A61N5/10 , A61K31/4162 , A61K45/06 , A61K31/5377 , A61K31/496
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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公开(公告)号:US07407971B2
公开(公告)日:2008-08-05
申请号:US10539145
申请日:2003-12-04
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/454 , C07D401/14
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: A new class of pyrazolo derivative compounds having the formula where R and R1 have the meanings given herein. The pyrazolo derivative compounds are useful in treating cell proliferative disorders caused by and/or associated with an altered cell cycle dependent kinase activity in mammals. The compounds may be provided in pharmaceutical compositions or in a kit.
摘要翻译: 一类新的具有下式的吡唑衍生物化合物其中R 1和R 2具有本文给出的含义。 吡唑衍生物化合物可用于治疗由哺乳动物中改变的细胞周期依赖性激酶活性引起的和/或与其相关的细胞增殖性疾病。 化合物可以以药物组合物或试剂盒提供。
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公开(公告)号:US08557857B2
公开(公告)日:2013-10-15
申请号:US12181772
申请日:2008-07-29
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/4162 , C07D487/02
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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公开(公告)号:US08557845B2
公开(公告)日:2013-10-15
申请号:US13614545
申请日:2012-09-13
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/454 , C07D401/14
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
摘要翻译: 公开了由式(Ia)或(Ib)表示的化合物及其中R和R 1如说明书中所定义的化合物及其药学上可接受的盐; 所述化合物可用于治疗细胞周期增殖性疾病,例如, 与改变的细胞周期依赖性激酶活性相关的癌症。
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公开(公告)号:US20130017170A1
公开(公告)日:2013-01-17
申请号:US13614499
申请日:2012-09-13
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/4162 , A61K31/496 , A61K31/454 , A61K31/5377 , C40B40/04 , A61P35/00 , A61P37/00 , A61P9/00 , A61P31/00 , C07D487/04 , A61K38/21
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
摘要翻译: 公开了由式(Ia)或(Ib)表示的化合物及其中R和R 1如说明书中所定义的化合物及其药学上可接受的盐; 所述化合物可用于治疗细胞周期增殖性疾病,例如, 与改变的细胞周期依赖性激酶活性相关的癌症。
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公开(公告)号:US20130012507A1
公开(公告)日:2013-01-10
申请号:US13614545
申请日:2012-09-13
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/4162 , A61P35/00 , A61K31/496 , A61K31/5377 , C07D487/04 , A61K31/454
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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公开(公告)号:US08785448B2
公开(公告)日:2014-07-22
申请号:US14010819
申请日:2013-08-27
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/496 , C07D403/14
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
摘要翻译: 公开了由式(Ia)或(Ib)表示的化合物及其中R和R 1如说明书中所定义的化合物及其药学上可接受的盐; 所述化合物可用于治疗细胞周期增殖性疾病,例如, 与改变的细胞周期依赖性激酶活性相关的癌症。
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公开(公告)号:US20090082346A1
公开(公告)日:2009-03-26
申请号:US12181772
申请日:2008-07-29
申请人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Gabriella Brasca , Raffaella Amici , Daniele Fancelli , Marcella Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: C07D471/04 , A61K31/4162 , A61K31/5377 , A61K31/497 , A61P35/04
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
摘要翻译: 公开了由式(Ia)或(Ib)表示的化合物及其中R和R 1如说明书中所定义的化合物及其药学上可接受的盐; 所述化合物可用于治疗细胞周期增殖性疾病,例如, 与改变的细胞周期依赖性激酶活性相关的癌症。
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公开(公告)号:US20070004705A1
公开(公告)日:2007-01-04
申请号:US10539145
申请日:2003-12-04
申请人: Maria Brasca , Raffaella Amici , Daniele Fancelli , Marcell Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
发明人: Maria Brasca , Raffaella Amici , Daniele Fancelli , Marcell Nesi , Paolo Orsini , Fabrizio Orzi , Patrick Roussel , Anna Vulpetti , Paolo Pevarello
IPC分类号: A61K31/551 , A61K31/496 , A61K31/4747 , A61K31/454 , A61K31/4162 , C07D487/10 , C07D487/02
CPC分类号: C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
摘要翻译: 通式(Ia)或(Ib)表示的化合物及其药学上可接受的盐及其药学上可接受的盐被公开,其中R 1和R 1'如说明书中所定义。 所述化合物可用于治疗细胞周期增殖性疾病,例如, 与改变的细胞周期依赖性激酶活性相关的癌症。
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