发明申请
US20130018455A1 METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT
审中-公开
使用静脉阻塞血管紧张素血症的方法
- 专利标题: METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT
- 专利标题(中): 使用静脉阻塞血管紧张素血症的方法
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申请号: US13561828申请日: 2012-07-30
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公开(公告)号: US20130018455A1公开(公告)日: 2013-01-17
- 发明人: Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
- 申请人: Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
- 申请人地址: JP Okayama JP Kyoto JP Hiroshima JP Tokyo
- 专利权人: JAPAN STENT TECHNOLOGY CO., LTD.,HIROO IWATA,TOYO ADVANCED TECHNOLOGIES CO., LTD.,TOKAI UNIVERSITY EDUCATIONAL SYSTEM
- 当前专利权人: JAPAN STENT TECHNOLOGY CO., LTD.,HIROO IWATA,TOYO ADVANCED TECHNOLOGIES CO., LTD.,TOKAI UNIVERSITY EDUCATIONAL SYSTEM
- 当前专利权人地址: JP Okayama JP Kyoto JP Hiroshima JP Tokyo
- 优先权: JP2007-228788 20070904
- 主分类号: A61F2/82
- IPC分类号: A61F2/82 ; A61K9/00
摘要:
A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
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