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    Dental composition kit
    1.
    发明授权
    Dental composition kit 有权
    牙科成分包

    公开(公告)号：US06869984B2

    公开(公告)日：2005-03-22

    申请号：US10171596

    申请日：2002-06-17

    申请人： Mitsunobu Kawashima ,  Ikuo Omura ,  Mayumi Yamashita

    发明人： Mitsunobu Kawashima ,  Ikuo Omura ,  Mayumi Yamashita

    IPC分类号： A61K6/00 ,  A61K6/083 ,  C08K3/34

    CPC分类号： A61K6/0835 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0038 ,  A61K6/083 ,  C08L33/00

    摘要： The invention refers to a dental composition kit which comprises a combination of (A) a one-pack primer composition containing (a) an acid group-having polymerizable monomer and (b) an aromatic secondary amine and/or an aromatic tertiary amine, and (B) a cement composition containing (c) a polyalkenoic acid, (d) an ion-leachable glass filler, (e) a polymerizable monomer, (f) water, (g) a peroxide and (h) a salt of an aromatic sulfinic acid. A dental composition kit of this invention is easy to handle, and the cured product of the compositions bonds well to teeth. The kit is useful in restoring decayed or injured teeth and in bonding prostheses to teeth.

    摘要翻译： 本发明涉及一种牙科用组合物试剂盒，其包含（A）含有（a）含酸基的可聚合单体和（b）芳族仲胺和/或芳族叔胺的单组分底漆组合物的组合，和 （B）含有（c）聚链烯酸的水泥组合物，（d）可离子浸出的玻璃填料，（e）可聚合单体，（f）水，（g）过氧化物和（h） 亚磺酸。 本发明的牙科用组合物试剂盒易于处理，组合物的固化物与牙齿粘合良好。 该套件可用于恢复蛀牙或受伤的牙齿以及将假体粘合到牙齿上。

    Molded polymer article having a hydrophilic surface and process for producing the same
    2.
    发明授权
    Molded polymer article having a hydrophilic surface and process for producing the same 失效
    具有亲水性表面的成型聚合物制品及其制造方法

    公开(公告)号：US06310116B1

    公开(公告)日：2001-10-30

    申请号：US09157100

    申请日：1998-09-18

    申请人： Tokugen Yasuda ,  Hitoshi Inoue ,  Satsuki Kitajima ,  Masahiro Sato ,  Wu Yang ,  Ikuo Omura

    发明人： Tokugen Yasuda ,  Hitoshi Inoue ,  Satsuki Kitajima ,  Masahiro Sato ,  Wu Yang ,  Ikuo Omura

    IPC分类号： G02C704

    CPC分类号： C08J5/00

    摘要： A molded polymer article comprises a main molded body having on the surface thereof a hydrophilic polymer layer, the article being obtained by polymerizing both a monomer having a hydrophilic group and coated on the surface of a hydrophilic mold, and a polymerizable composition consisting essentially of a monomer and/or oligomer and placed in the mold. The hydrophilic polymer layer has excellent adhesiveness to the main body of the molded polymer article and excellent durability, so that the high hydrophilic property can be maintained, even when the article is exposed to external forces such as friction, over a long period of time. The molded articles are therefore useful as, in particular, contact lenses.

    摘要翻译： 模制的聚合物制品包括在其表面上具有亲水性聚合物层的主要成型体，该制品通过聚合具有亲水基团的单体并涂覆在亲水性模具的表面上而获得，以及可聚合组合物，其基本上由 单体和/或低聚物并置于模具中。 亲水性聚合物层与模塑聚合物制品的主体具有优异的粘合性，并且具有优异的耐久性，即使当制品长时间暴露于诸如摩擦的外力时，也能保持高的亲水性。 因此，模塑制品可用作特别是隐形眼镜。

    Adhesive composition
    4.
    发明授权
    Adhesive composition 失效
    粘合剂组合物

    公开(公告)号：US4650847A

    公开(公告)日：1987-03-17

    申请号：US720012

    申请日：1985-04-04

    申请人： Ikuo Omura ,  Junichi Yamauchi ,  Yoshinori Nagase ,  Fumiko Uemura

    发明人： Ikuo Omura ,  Junichi Yamauchi ,  Yoshinori Nagase ,  Fumiko Uemura

    IPC分类号： A61K6/00 ,  C07F9/09 ,  C08F4/34 ,  C09J4/00 ,  A61K6/02 ,  C09K3/00

    CPC分类号： C09J4/00 ,  A61K6/0088 ,  A61K6/0091 ,  C07F9/091

    摘要： An adhesive composition comprises 100 parts by weight of a polymerizable monomer comprising (a) 1.5 to 100 parts by weight of a compound represented by general formula I or II: ##STR1## where R.sub.1 and R.sub.1 ' each stand for hydrogen or a methyl group, R.sub.2 stands for a divalent organic residue having 4 to 40 carbon atoms, X.sub.1 and X.sub.2 each stand for --O--, --S-- or --NH--, a is 0 or 1, and R.sub.3 stands for a group of the formula ##STR2## having 6 to 40 carbon atoms, where R.sub.4 and R.sub.4 ' each stand for a hydrocarbon group having 1 to 29 carbon atoms, and optionally replaced by a halogen atom, or a hydroxyl, amino or carboxyl group, b is an integer of 0 to 3, and Z stands for --O--, --COO-- or --NH--, a plurality of R.sub.4 ' (when b is 2 or 3) being the same or different, at least one of R.sub.4 and R.sub.4 ' having at least three carbon atoms, and (b) 0 to 98.5 parts by weight of a vinyl monomer copolymerizable with the above compound; and 0.01 to 20 parts by weight of a curing agent. It shows a superior adhesive strength on any of hard tissues in a living body, such as teeth and bones, metals, organic polymers and ceramics. It maintains a high adhesive strength for a long time even if it is exposed to moisture, or immersed in water. It is particularly effective for use in dentistry, though it is useful for a variety of other purposes, too.

    摘要翻译： 粘合剂组合物包含100重量份的可聚合单体，其包含（a）1.5至100重量份的由通式I或II表示的化合物：其中R 1和R 1 '各自代表氢或甲基，R2代表具有4-40个碳原子的二价有机残基，X1和X2分别表示-O - ， - S-或-NH-，a是0或1，R3 代表具有6〜40个碳原子的式“IMAGE”的基团，其中R 4和R 4'各自代表具有1至29个碳原子的烃基，并且任选被卤素原子或羟基，氨基或羧基取代 基团，b为0〜3的整数，Z表示-O - ， - COO-或-NH-，多个R 4'（当b为2或3）相同或不同时， R4和R4'具有至少三个碳原子，和（b）0至98.5重量份可与上述化合物共聚的乙烯基单体; 和0.01〜20重量份的固化剂。 它对生物体中的任何硬组织如牙齿和骨骼，金属，有机聚合物和陶瓷显示出优异的粘合强度。 即使暴露于潮湿或浸入水中，也能长时间保持高粘合强度。 它在牙科使用中特别有效，尽管它也适用于各种其他目的。

    Method of inhibiting vascular intimal hyperplasia using stent
    6.
    发明授权
    Method of inhibiting vascular intimal hyperplasia using stent 有权
    使用支架抑制血管内膜增生的方法

    公开(公告)号：US08968392B2

    公开(公告)日：2015-03-03

    申请号：US13561828

    申请日：2012-07-30

    申请人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    IPC分类号： A61F2/82 ,  A61F2/00 ,  A61L33/00 ,  A61F2/915 ,  A61K9/00 ,  A61L31/10 ,  A61L31/16 ,  A61F2/91

    CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.

    摘要翻译： 一种抑制血管内膜增生的方法，包括：将支架放置在血管内，所述支架具有圆柱形构造的支架主体，其外表面和内表面具有涂覆在其上的金刚石状薄膜，第一涂层涂层 至少支架体的外表面，第一涂层由包含生物可降解聚合物和一种血管内膜增生抑制剂的第一组合物制成，其包含不抑制内皮细胞增殖的阿加曲班，其重量组成比 血管内膜增生抑制剂的聚合物在8:2至7:3的范围内，以及第二涂层; 并使阿加曲班从支架释放，从而抑制血管内膜增生而不抑制内皮细胞的增殖。

    METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT
    7.
    发明申请
    METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT 审中-公开
    使用静脉阻塞血管紧张素血症的方法

    公开(公告)号：US20130018455A1

    公开(公告)日：2013-01-17

    申请号：US13561828

    申请日：2012-07-30

    申请人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    IPC分类号： A61F2/82 ,  A61K9/00

    CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.

    摘要翻译： 一种抑制血管内膜增生的方法，包括：将支架放置在血管内，所述支架具有圆柱形构造的支架主体，其外表面和内表面具有涂覆在其上的金刚石状薄膜，第一涂层涂层 至少支架体的外表面，第一涂层由包含生物可降解聚合物和一种血管内膜增生抑制剂的第一组合物制成，其包含不抑制内皮细胞增殖的阿加曲班，其重量组成比 血管内膜增生抑制剂的聚合物在8:2至7:3的范围内，以及第二涂层; 并使阿加曲班从支架释放，从而抑制血管内膜增生而不抑制内皮细胞的增殖。

    Sustained drug-releasing stent
    8.
    发明申请
    Sustained drug-releasing stent 审中-公开
    持续放药支架

    公开(公告)号：US20100249914A1

    公开(公告)日：2010-09-30

    申请号：US12801307

    申请日：2010-06-02

    申请人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    IPC分类号： A61F2/82 ,  B05D3/00

    CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.

    摘要翻译： 支架包括具有外表面和内表面的圆柱形构造的支架体，至少涂覆外表面的第一涂层，以及基本上完全覆盖在第一涂层上的第二涂层涂层。 第一涂层由包含不抑制内皮细胞增殖的聚合物和血管内膜增生抑制剂（优选阿加曲班）的第一组合物制备，聚合物与抑制剂的重量组成比在该范围内 8：2到3：7。 另一方面，第二涂层由单独的聚合物或包含聚合物和药物的第二组合物制备，所述药物与所述聚合物的80重量％的重量组成比小于20重量％。

    Method of bonding a metal or alloy utilizing a polymerizable thiocarboxylic acid or a derivative thereof
    10.
    发明授权
    Method of bonding a metal or alloy utilizing a polymerizable thiocarboxylic acid or a derivative thereof 失效
    利用可聚合的硫代羧酸或其衍生物键合金属或合金的方法

    公开(公告)号：US5254198A

    公开(公告)日：1993-10-19

    申请号：US892928

    申请日：1992-06-03

    申请人： Mitsunobu Kawashima ,  Ikuo Omura

    发明人： Mitsunobu Kawashima ,  Ikuo Omura

    IPC分类号： A61K6/00 ,  A61K6/083 ,  C09J4/00 ,  C09J5/02

    CPC分类号： C09J4/00 ,  A61K6/0029

    摘要： An adhesive composition comprising a polymerizable thiocarboxylic acid or a derivative thereof of the general formula ##STR1## wherein X.sub.1 is an oxygen atom or a sulfur atom and where X.sub.1 is an oxygen atom, R.sub.1 is an organic group containing at least one olefinic double bond and R.sub.2 is a mercapto group, and where X.sub.1 is a sulfur atom, R.sub.1 is an organic group and R.sub.2 is a mercapto group, a halogen atom, --OR.sub.3, or --SR.sub.3, where R.sub.3 is a monovalent organic group, and at least one of R.sub.1 and R.sub.3 has at least one olefinic double bond, are useful as primers or adhesives and provide a water-resistant, high-strength bond to noble metal adherends which are used in dental and other applications.

    摘要翻译： 一种粘合剂组合物，其包含通式“IMAGE”的可聚合的硫代羧酸或其衍生物，其中X 1是氧原子或硫原子，并且其中X 1是氧原子，R 1是含有至少一个烯属双键的有机基团， R2是巯基，其中X1是硫原子，R1是有机基团，R2是巯基，卤素原子，-OR3或-SR3，其中R3是一价有机基团，以及至少一种 R1和R3具有至少一个烯属双键，可用作底漆或粘合剂，并且在用于牙科和其它应用中的贵金属被粘物上提供耐水，高强度的粘合。