发明申请
US20130022629A1 Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
审中-公开
免疫抑制受体PD-1的调节剂及其使用方法
- 专利标题： Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
- 专利标题（中）： 免疫抑制受体PD-1的调节剂及其使用方法
-
申请号： US13519621申请日： 2011-01-03
-
公开(公告)号： US20130022629A1公开(公告)日： 2013-01-24
- 发明人: Arlene H. Sharpe , Manish J. Butte , Shinji Oyama
- 申请人： Arlene H. Sharpe , Manish J. Butte , Shinji Oyama
- 国际申请： PCT/US2011/020046 WO 20110103
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K31/4439 ; A61K31/44 ; A61K31/433 ; C07D239/42 ; A61P41/00 ; C07D211/98 ; C07D285/135 ; A61P31/00 ; A61P35/00 ; A61P37/02 ; A61K39/00 ; C07D417/12
摘要：
Disclosed are an assay to identify modulators of the PD-1:PD-L pathway and PD-1:PD-L pathway modulators, e.g., compounds and pharmaceutical compositions thereof. Methods for treating diseases influenced by modulation of the PD-1:PD-L pathway such as, for example, autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, immune deficiency, and other immune system-related disorders, are also disclosed.
信息查询
