发明申请
- 专利标题： CLASSIFICATION OF NUCLEIC ACID TEMPLATES
- 专利标题（中）： 核酸模板分类
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申请号： US13633673申请日： 2012-10-02
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公开(公告)号： US20130029853A1公开(公告)日： 2013-01-31
- 发明人: Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes , Joseph Puglisi
- 申请人： Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes , Joseph Puglisi
- 申请人地址： US CA Menlo Park
- 专利权人： Pacific Biosciences of California, Inc.
- 当前专利权人： Pacific Biosciences of California, Inc.
- 当前专利权人地址： US CA Menlo Park
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/70 ; C40B20/00 ; G01N21/64 ; B82Y15/00
摘要：
Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
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