- 专利标题： SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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申请号： US13451574申请日： 2012-04-20
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公开(公告)号： US20130029987A1公开(公告)日： 2013-01-31
- 发明人: Brydon L. Bennett , Jan Elsner , Paul Erdman , Robert Hilgraf , Laurie Ann LeBrun , Meg McCarrick , Mehran F. Moghaddam , Mark A. Nagy , Stephen Norris , David A. Paisner , Marianne Sloss , William J. Romanow , Yoshitaka Satoh , Jayashree Tikhe , Won Hyung Yoon , Mercedes Delgado
- 申请人： Brydon L. Bennett , Jan Elsner , Paul Erdman , Robert Hilgraf , Laurie Ann LeBrun , Meg McCarrick , Mehran F. Moghaddam , Mark A. Nagy , Stephen Norris , David A. Paisner , Marianne Sloss , William J. Romanow , Yoshitaka Satoh , Jayashree Tikhe , Won Hyung Yoon , Mercedes Delgado
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; C07D405/12 ; C07D401/12 ; A61K31/506 ; C07D405/14 ; C12N5/071 ; C07D413/12 ; A61K31/5377 ; A61P1/16 ; A61P3/10 ; A61P3/00 ; C07D239/48 ; C07D403/12
摘要：
Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.
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