- 专利标题： COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION
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申请号： US13566922申请日： 2012-08-03
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公开(公告)号： US20130035370A1公开(公告)日： 2013-02-07
- 发明人: C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
- 申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： A61K31/712
- IPC分类号： A61K31/712 ; C12N5/071
摘要：
Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
公开/授权文献
- US08791088B2 Compositions and methods for modulation of LMNA expression 公开/授权日：2014-07-29
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