发明申请
US20130035472A1 METHOD OF PRODUCING TRANSCRIPTS USING CRYPTIC SPLICE SITES
审中-公开
使用CRYPTIC SPLICE SITES生成转录的方法
- 专利标题： METHOD OF PRODUCING TRANSCRIPTS USING CRYPTIC SPLICE SITES
- 专利标题（中）： 使用CRYPTIC SPLICE SITES生成转录的方法
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申请号： US13634279申请日： 2011-03-15
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公开(公告)号： US20130035472A1公开(公告)日： 2013-02-07
- 发明人: Robert Horlick , John Macomber , Andrew Cubitt , David King
- 申请人： Robert Horlick , John Macomber , Andrew Cubitt , David King
- 申请人地址： US CA San Diego
- 专利权人： ANAPTYSBIO, INC.
- 当前专利权人： ANAPTYSBIO, INC.
- 当前专利权人地址： US CA San Diego
- 国际申请： PCT/US11/28529 WO 20110315
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C12P19/34 ; C07K14/00 ; C12N5/10 ; C12N15/63 ; C12N1/21 ; C12N1/19 ; C07H1/00 ; C07K19/00
摘要：
The invention is directed to a method of preparing a nucleic acid sequence with a modified splice site usage profile, which employs the use of a nucleic acid sequence comprising a cryptic splice donor site. The invention also provides a method of producing an alternate form of an RNA molecule encoded by a nucleic acid sequence, which nucleic acid sequence comprises a cryptic splice donor site, a heterologous nucleic acid sequence, and a splice acceptor site.