发明申请
US20130053381A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES
审中-公开
2,4-二氧-1,4-二氢-2H-喹唑啉-3-基磺酰胺衍生物
- 专利标题： 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES
- 专利标题（中）： 2,4-二氧-1,4-二氢-2H-喹唑啉-3-基磺酰胺衍生物
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申请号： US13638082申请日： 2011-05-18
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公开(公告)号： US20130053381A1公开(公告)日： 2013-02-28
- 发明人: Yves Auberson , David Carcache , Andreas Lerchner , Joachim Nozulak
- 申请人： Yves Auberson , David Carcache , Andreas Lerchner , Joachim Nozulak
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 国际申请： PCT/EP2011/058068 WO 20110518
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; C07D239/96 ; C07D413/14 ; A61K31/5377 ; C07D405/10 ; A61P21/00 ; A61P25/28 ; A61P25/00 ; A61P25/16 ; A61P25/18 ; A61P1/08 ; A61P27/16 ; A61K31/517 ; A61P25/08
摘要：
The invention relates to a 2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl-sulfonamide derivative being (A) a compound of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; or (B) a compound selected from a certain group of 2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl-sulfonamide derivatives disclosed in the specification; in free form or in salt form; to their preparation, to their use as medicament and to medicaments comprising them. In a first aspect, the invention provides prodrugs of AMPA receptor antagonists which potentially useful in the treatment of a wide range of disorders, particularly epilepsy.
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