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1.发明授权Substituted 1H-quinazoline-2,4-diones useful as AMPA receptor ligands 失效可用作AMPA受体配体的取代的1H-喹唑啉-2,4-二酮公开(公告)号：US07655666B2
公开(公告)日：2010-02-02
申请号：US11911040
申请日：2006-04-10
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
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公开(公告)号：US20100144747A1
公开(公告)日：2010-06-10
申请号：US12569402
申请日：2009-09-29
申请人： Hans ALLGEIER , Yves AUBERSON , David CARCACHE , Philipp FLOERSHEIM , Christel GUIBOURDENCHE , Wolfgang FROESTL , Jörg KALLEN , Manuel KOLLER , Henri MATTES , Joachim NOZULAK , David ORAIN , Johanne RENAUD
发明人： Hans ALLGEIER , Yves AUBERSON , David CARCACHE , Philipp FLOERSHEIM , Christel GUIBOURDENCHE , Wolfgang FROESTL , Jörg KALLEN , Manuel KOLLER , Henri MATTES , Joachim NOZULAK , David ORAIN , Johanne RENAUD
IPC分类号： A61K31/501 , C07D239/72 , A61K31/517 , C07D403/02
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了制备式（I）化合物的中间体和包含式（I）化合物的组合物。
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公开(公告)号：US20080153836A1
公开(公告)日：2008-06-26
申请号：US11911040
申请日：2006-04-10
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jorg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jorg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/501 , C07D239/72 , A61K31/517 , A61P25/00 , C07D237/06
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如本说明书中所定义，它们的制备，它们的 用作药物，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
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4.发明授权1H-quinazoline-2,4-diones processes for their production, pharmaceutical compositions, and treatment for epilepsy 失效1H-喹唑啉-2,4-二酮的制备方法，药物组合物和治疗癫痫公开(公告)号：US08513268B2
公开(公告)日：2013-08-20
申请号：US13192816
申请日：2011-07-28
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
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公开(公告)号：US20090286827A1
公开(公告)日：2009-11-19
申请号：US12296034
申请日：2007-04-02
IPC分类号： A61K31/437 , C07D401/04 , C07D471/04 , C07D487/00 , A61K31/4439 , A61K31/4162
CPC分类号： C07D401/04 , C07D471/04 , C07D487/04
摘要： The present invention relates to novel bi-aryl amines of formula (I) and to pharmaceutically acceptable prodrugs, salts, solvates, hydrates, and N-oxides thereof and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
摘要翻译： 本发明涉及式（I）的新型双芳基胺及其药学上可接受的前药，盐，溶剂合物，水合物和N-氧化物，以及包含它们的药物组合物，其使用方法及其制备方法。
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公开(公告)号：US20140357625A1
公开(公告)日：2014-12-04
申请号：US14462813
申请日：2014-08-19
申请人： Dirk BEHNKE , David CARCACHE , Peter ERTL , Manuel KOLLER , David ORAIN
发明人： Dirk BEHNKE , David CARCACHE , Peter ERTL , Manuel KOLLER , David ORAIN
IPC分类号： C07D498/04 , C07D471/14 , C07D471/04
CPC分类号： C07D471/04 , A61K31/551 , A61K45/06 , C07D471/14 , C07D498/04 , C07D519/00
摘要： The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译： 本发明涉及式I化合物或其盐，其中取代基如说明书中所定义; 作为其制备，用作药物和包含它的药物。
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公开(公告)号：US08853203B2
公开(公告)日：2014-10-07
申请号：US13973454
申请日：2013-08-22
申请人： Dirk Behnke , David Carcache , Peter Ertl , Manuel Koller , David Orain
发明人： Dirk Behnke , David Carcache , Peter Ertl , Manuel Koller , David Orain
IPC分类号： C07D471/04 , C07D471/14 , A61K31/551 , A61P25/00 , C07D498/04 , A61K45/06
CPC分类号： C07D471/04 , A61K31/551 , A61K45/06 , C07D471/14 , C07D498/04 , C07D519/00
摘要： The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
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公开(公告)号：US20140057902A1
公开(公告)日：2014-02-27
申请号：US13973454
申请日：2013-08-22
申请人： Dirk BEHNKE , David CARCACHE , Peter ERTL , Manuel KOLLER , David ORAIN
发明人： Dirk BEHNKE , David CARCACHE , Peter ERTL , Manuel KOLLER , David ORAIN
IPC分类号： C07D471/04 , A61K45/06 , C07D471/14 , A61K31/551 , C07D498/04
CPC分类号： C07D471/04 , A61K31/551 , A61K45/06 , C07D471/14 , C07D498/04 , C07D519/00
摘要： The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译： 本发明涉及式I化合物或其盐，其中取代基如说明书中所定义; 作为其制备，用作药物和包含它的药物。
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公开(公告)号：US20110294818A1
公开(公告)日：2011-12-01
申请号：US13192816
申请日：2011-07-28
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517 , C07D403/10 , C07D405/10 , C07D401/10 , C07C229/66 , C07C229/64 , C07D307/16 , C07D309/12 , C07C265/12 , C07D231/12 , C07D249/06 , C07D207/337 , C07C205/57 , C07D237/08 , A61P25/08 , A61P25/18 , C07D239/96
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
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10.发明授权N-(2,4-dioxo-6-(tetrahydrofuran-2-yl)-7-(trifluoromethyl)-1,4-dihydro-2H-quinazolin-3-yl)methanesulfonamide 失效N-（2,4-二氧代-6-（四氢呋喃-2-基）-7-（三氟甲基）-1,4-二氢-2H-喹唑啉-3-基）甲磺酰胺公开(公告)号：US08012988B2
公开(公告)日：2011-09-06
申请号：US12569402
申请日：2009-09-29
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
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