发明申请
- 专利标题: Diazeniumdiolate Cyclohexyl Derivatives
- 专利标题(中): 二氮烯二硫代环己基衍生物
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申请号: US13698444申请日: 2011-05-16
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公开(公告)号: US20130059823A1公开(公告)日: 2013-03-07
- 发明人: Amjad Ali , Lin Yan , Pei Huo , Ravi Nargund
- 申请人: Amjad Ali , Lin Yan , Pei Huo , Ravi Nargund
- 优先权: US61347042 20100521
- 国际申请: PCT/US11/36607 WO 20110516
- 主分类号: A61K31/655
- IPC分类号: A61K31/655 ; A61P9/12 ; C07C245/02
摘要:
A compound having the structure (I) or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, deuterium, —OH, —OC1-6alkyl, or halogen; R8 is hydrogen, deuterium, or C1-6alkyl; R11 and R12 are independently hydrogen, —C1-6alkyl, —OH, —OC1-6alkyl, or halogen; R13 and R14 are independently —C1-6alkyl, —(CH2)1-2OH, or —OC1-6alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or —C1-6alkyl; R15 is (CR1R2)nC(O)OR16, wherein n is 0, 1 or 2, —C(O)NHCH(R17)OR16, or —C(O)NHCH(R17)C(O)NHCH(R18)C(O)OR16; R16 is hydrogen, C1-6alkyl, or (CH2)1-2N+R19R20R21; R1, R2, R4, R5, R6, R7, R9, R10, R17, R18, R19, R20, and R21 are independently hydrogen or —C1-6alkyl; and stereoisomers thereof, and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts of stereoisomers thereof.
公开/授权文献
- US08623846B2 Diazeniumdiolate cyclohexyl derivatives 公开/授权日:2014-01-07
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