发明申请
- 专利标题: INTEGRIN ALPHA-V BETA8 NEUTRALIZING ANTIBODY
- 专利标题(中): INTEGRIN ALPHA-V BETA8中和抗体
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申请号: US13580105申请日: 2011-02-18
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公开(公告)号: US20130064837A1公开(公告)日: 2013-03-14
- 发明人: Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James D. Marks
- 申请人: Stephen Nishimura , Jianlong Lou , Jody Lynn Baron , James D. Marks
- 申请人地址: US CA Oakland
- 专利权人: The Regents of the University of California
- 当前专利权人: The Regents of the University of California
- 当前专利权人地址: US CA Oakland
- 国际申请: PCT/US11/25514 WO 20110218
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C12N15/85 ; C12N5/10 ; G01N33/566 ; C07K16/46 ; A61P35/04 ; A61P11/00 ; A61P11/06 ; A61P29/00 ; A61P37/06 ; A61P25/00 ; A61P35/00 ; C12N15/13 ; A61K39/395
摘要:
The present invention relates to ανβ8 antagonists, anti-ανβ8 antibodies or immunoconjugates for reducing TGFβ activation in an individual. Further provided are compositions comprising one of the ανβ8 antagonists, anti-ανβ8 antibodies or immunoconjugates, methods for using the compositions, and related subject matter.
公开/授权文献
- US09290572B2 Integrin α-Vβ8 neutralizing antibody 公开/授权日:2016-03-22
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