- 专利标题： TREATMENT OF SIRTUIN (SIRT) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A SIRTUIN (SIRT)
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申请号： US13695801申请日： 2011-01-13
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公开(公告)号： US20130072421A1公开(公告)日： 2013-03-21
- 发明人: Joseph Collard , Olga Khorkova Sherman , Carlos Coito , Belinda De Leon
- 申请人： Joseph Collard , Olga Khorkova Sherman , Carlos Coito , Belinda De Leon
- 申请人地址： US FL Miami
- 专利权人： CURNA, INC
- 当前专利权人： CURNA, INC
- 当前专利权人地址： US FL Miami
- 国际申请： PCT/US11/21052 WO 20110113
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61P9/10 ; A61P31/18 ; A61P1/16 ; A61P3/04 ; A61P3/10 ; A61P3/06 ; A61P1/04 ; A61P7/00 ; A61P17/08 ; A61P19/02 ; A61P19/08 ; A61P19/10 ; A61P25/00 ; A61P25/28 ; A61P25/02 ; A61P17/00 ; A61P35/00 ; A61P35/02 ; A61P27/02 ; A61K38/14 ; C07K2/00 ; C07H21/04 ; A61P21/00 ; A61P3/00 ; A61P29/00 ; A61P25/32 ; A61P27/12 ; A61P1/00 ; A61P11/00 ; A61P13/00 ; C07H21/02 ; C12N5/071
摘要：
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Sirtuin (SIRT), in particular, by targeting natural antisense polynucleotides of a Sirtuin (SIRT). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Sirtuins (SIRT)s.
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