A pneumatic run flat tire includes an inner side reinforcing rubber layer having a falcated cross-section and an outer side reinforcing rubber layer having a center of gravity position in a meridian cross-section that is positioned inward in a tire radial direction of a tire maximum width position disposed in a side wall portion. Volumes of the inner side reinforcing rubber layer and the outer side reinforcing rubber layer are each different on a vehicle inner side and a vehicle outer side when mounted on a vehicle.