发明申请
- 专利标题： Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof
- 专利标题（中）： 椎间盘髓核干细胞/祖细胞，培养方法及其用途
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申请号： US13637470申请日： 2011-03-29
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公开(公告)号： US20130078222A1公开(公告)日： 2013-03-28
- 发明人: Daisuke Sakai , Joji Mochida , Kiyoshi Ando , Yoshihiko Nakamura
- 申请人： Daisuke Sakai , Joji Mochida , Kiyoshi Ando , Yoshihiko Nakamura
- 申请人地址： JP Tokyo
- 专利权人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM
- 当前专利权人： TOKAI UNIVERSITY EDUCATIONAL SYSTEM
- 当前专利权人地址： JP Tokyo
- 优先权： JP2010-077743 20100330
- 国际申请： PCT/JP2011/057750 WO 20110329
- 主分类号： C12N5/071
- IPC分类号： C12N5/071
摘要：
Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and is positive for at least one surface marker from among Tie2 and GD2. That is, the intervertebral disk nucleus pulposus stem cell is characterized by being at least Tie2-positive for the surface marker and) possesses a self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. Also provided is an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.
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