发明申请
- 专利标题： NEW BICYCLIC DIHYDROQUINOLINE-2-ONE DERIVATIVES
- 专利标题（中）： 新的双环二氢喹啉-2-酮衍生物
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申请号： US13615901申请日： 2012-09-14
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公开(公告)号： US20130079365A1公开(公告)日： 2013-03-28
- 发明人: Johannes Aebi , Kurt Amrein , Serena Maria Fantasia , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Michelangelo Scalone , Xuefei Tan , Mingwei Zhou
- 申请人： Johannes Aebi , Kurt Amrein , Serena Maria Fantasia , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Michelangelo Scalone , Xuefei Tan , Mingwei Zhou
- 优先权： CNPCT/CN2011/080078 20110923
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; A61K31/4725 ; A61P9/12 ; A61P13/12 ; A61P9/04 ; C07D401/10 ; C07D471/04
摘要：
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 A3 and n are as described herein, compositions including the compounds and methods of using the compounds.The compounds of the present invention are useful as inhibitors of aldosterone synthase. The compounds may be used, for example, in the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
公开/授权文献
- US09353081B2 Bicyclic dihydroquinoline-2-one derivatives 公开/授权日：2016-05-31
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