发明申请
US20130079366A1 Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction
有权
苯并恶唑和偶氮苯并恶唑作为MGLUR4变构电位器，组合物和治疗神经功能障碍的方法
- 专利标题： Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction
- 专利标题（中）： 苯并恶唑和偶氮苯并恶唑作为MGLUR4变构电位器，组合物和治疗神经功能障碍的方法
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申请号： US13578802申请日： 2011-02-11
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公开(公告)号： US20130079366A1公开(公告)日： 2013-03-28
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
- 申请人地址： US TN Nashville
- 专利权人： VANDERBILT UNIVERSITY
- 当前专利权人： VANDERBILT UNIVERSITY
- 当前专利权人地址： US TN Nashville
- 国际申请： PCT/US11/24627 WO 20110211
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K31/437 ; A61K31/423 ; A61K45/06 ; C07D261/20 ; C07D491/048 ; A61K31/4355
摘要：
Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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