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1.发明申请SUBSTITUTED DIOXOPIPERIDINES AND DIOXOPYRROLIDINES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权替代二氯吡啶和二氧化吡咯烷酮作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20110124663A1
公开(公告)日：2011-05-26
申请号：US12952640
申请日：2010-11-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
IPC分类号： A61K31/506 , A61K31/4439 , C07D401/12 , A61K31/4725 , A61K31/438 , C07D403/12 , A61K31/427 , C07D417/12 , A61P25/00 , A61P25/16 , C12N5/071
摘要： In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：其中变量在本文中定义，其可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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2.发明授权Benzisoxazoles and azabenzisoxazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权作为MGLUR4变构增强剂的苯并异恶唑和氮杂苯并恶唑，组合物和治疗神经功能障碍的方法公开(公告)号：US08916584B2
公开(公告)日：2014-12-23
申请号：US13578802
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
IPC分类号： C07D498/04 , C07D491/048 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20
CPC分类号： C07D498/04 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20 , C07D491/048
摘要： Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的苯并异恶唑和氮杂苯并恶唑化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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3.发明申请Heterocyclic Sulfone MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权杂环砜MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130158078A1
公开(公告)日：2013-06-20
申请号：US13697783
申请日：2011-05-12
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , A61K45/06 , C07D417/12
CPC分类号： A61K31/4439 , A61K45/06 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的杂环砜化合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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4.发明申请Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权苯并恶唑和偶氮苯并恶唑作为MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130079366A1
公开(公告)日：2013-03-28
申请号：US13578802
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
IPC分类号： C07D498/04 , A61K31/437 , A61K31/423 , A61K45/06 , C07D261/20 , C07D491/048 , A61K31/4355
CPC分类号： C07D498/04 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20 , C07D491/048
摘要： Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的苯并异恶唑和氮杂苯并恶唑化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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5.发明授权Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权吡唑并吡啶，吡咯并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US09163015B2
公开(公告)日：2015-10-20
申请号：US13578812
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/437 , A61K31/506 , C07D487/04 , C07D513/04 , C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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6.发明申请Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物作为MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130096110A1
公开(公告)日：2013-04-18
申请号：US13578812
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： C07D471/04 , A61K31/506 , A61K31/444 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/5377 , A61K31/497 , C07D513/04 , A61K31/429 , A61K31/4709 , A61K31/437 , A61K31/4985
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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7.发明授权Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权杂环砜mGluR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US09192603B2
公开(公告)日：2015-11-24
申请号：US13697783
申请日：2011-05-12
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , C07D417/12 , A61K45/06 , C07D401/12 , C07D413/12
CPC分类号： A61K31/4439 , A61K45/06 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的杂环砜化合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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8.发明授权Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US09108963B2
公开(公告)日：2015-08-18
申请号：US13584735
申请日：2012-08-13
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/437 , A61K31/506 , C07D487/04 , C07D513/04 , C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡唑并吡啶，吡唑并吡嗪，吡唑并嘧啶，吡唑并噻吩和吡唑并噻唑化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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9.发明授权MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 失效MGLUR4变构增强剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08779157B2
公开(公告)日：2014-07-15
申请号：US13394309
申请日：2010-09-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
IPC分类号： C07D233/00
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物及其用途。
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![Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction](/abs-image/US/2014/02/25/US08658650B2/abs.jpg.150x150.jpg)
10.发明授权Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权取代的1,1,3,1-四氧化苯并[D] [1,3,2]二噻唑作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08658650B2
公开(公告)日：2014-02-25
申请号：US13146909
申请日：2010-01-28
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
IPC分类号： A61K31/41 , A61K31/4439 , A61K31/506 , A61K31/444 , C07D417/12 , C07D419/14 , C07D285/01
CPC分类号： C07D285/01 , C07D403/12 , C07D417/12 , C07D417/14
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物和使用该化合物的方法。
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