发明申请
- 专利标题: MACROPOROUS BIOENGINEERED SCAFFOLDS FOR CELL TRANSPLANTATION
- 专利标题(中): 用于细胞移植的大面积生物制剂
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申请号: US13641034申请日: 2011-04-12
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公开(公告)号: US20130089594A1公开(公告)日: 2013-04-11
- 发明人: Cheryl Stabler Anderson , Eileen Pedraza , Christopher A. Fraker , Peter Buchwald , Norma Sue Kenyon , Luca Inverardi , Antonello Pileggi , Paul Latta , Jeffrey Hubbell , Jessica Weaver , Camillo D. Ricordi
- 申请人: Cheryl Stabler Anderson , Eileen Pedraza , Christopher A. Fraker , Peter Buchwald , Norma Sue Kenyon , Luca Inverardi , Antonello Pileggi , Paul Latta , Jeffrey Hubbell , Jessica Weaver , Camillo D. Ricordi
- 申请人地址: US FL Miami US FL Miami
- 专利权人: CONVERGE BIOTECH INC.,UNIVERSITY OF MIAMI
- 当前专利权人: CONVERGE BIOTECH INC.,UNIVERSITY OF MIAMI
- 当前专利权人地址: US FL Miami US FL Miami
- 国际申请: PCT/US11/32182 WO 20110412
- 主分类号: A61L27/18
- IPC分类号: A61L27/18 ; A61L27/26
摘要:
The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can provide mechanical protection to implanted cells, afford retrievability from a subject, and allow for both intra-device vascularization and a means to spatially distribute the cells within the device. The scaffold surface or material may be modified with one or more different adhesion proteins and optionally other biological factors for enhanced cell adherence and viability. Further, the scaffold surface or material may be modified with one or more agents with slow/sustained release characteristics to aid engraftment, survival, function or long-term viability. Implanted cells of the invention may be insulin-producing cells such as islets.