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公开(公告)号:US20130089594A1
公开(公告)日:2013-04-11
申请号:US13641034
申请日:2011-04-12
申请人: Cheryl Stabler Anderson , Eileen Pedraza , Christopher A. Fraker , Peter Buchwald , Norma Sue Kenyon , Luca Inverardi , Antonello Pileggi , Paul Latta , Jeffrey Hubbell , Jessica Weaver , Camillo D. Ricordi
发明人: Cheryl Stabler Anderson , Eileen Pedraza , Christopher A. Fraker , Peter Buchwald , Norma Sue Kenyon , Luca Inverardi , Antonello Pileggi , Paul Latta , Jeffrey Hubbell , Jessica Weaver , Camillo D. Ricordi
CPC分类号: A61L27/18 , A61K9/0024 , A61K35/12 , A61L27/26 , A61L27/3804 , A61L27/54 , A61L27/56 , A61L2300/414 , C12N5/0676 , C12N2533/30 , C08L83/04
摘要: The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can provide mechanical protection to implanted cells, afford retrievability from a subject, and allow for both intra-device vascularization and a means to spatially distribute the cells within the device. The scaffold surface or material may be modified with one or more different adhesion proteins and optionally other biological factors for enhanced cell adherence and viability. Further, the scaffold surface or material may be modified with one or more agents with slow/sustained release characteristics to aid engraftment, survival, function or long-term viability. Implanted cells of the invention may be insulin-producing cells such as islets.
摘要翻译: 本发明提供了高度多孔,生物相容性和生物稳定性的支架构架,用于改善整体细胞移植,存活,功能和长期存活力。 这些支架可以为植入细胞提供机械保护,从受试者提供可检索性,并且允许装置内血管化和在装置内空间分配细胞的手段。 支架表面或材料可以用一种或多种不同的粘附蛋白和任选的其它生物因子修饰,以增强细胞粘附和活力。 此外,支架表面或材料可以用一种或多种具有缓释/持续释放特性的试剂进行修饰以有助于植入,存活,功能或长期存活。 本发明的植入细胞可以是胰岛素产生细胞如胰岛。