发明申请
- 专利标题: Compounds Useful as Inhibitors of ATR Kinase
- 专利标题(中): 可用作ATR激酶抑制剂的化合物
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申请号: US13631732申请日: 2012-09-28
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公开(公告)号: US20130089625A1公开(公告)日: 2013-04-11
- 发明人: Jean-Damien Charrier , Pierre-Henri Storck , John Studley , Francoise Yvonne Theodora Marie Pierard , Steven John Durrant , Benjamin Joseph Littler , Paul Angell , Robert Michael Hughes , David Andrew Siesel , Armando Urbina , Carl Zwicker , Nicholas LoConte , Timothy Barder
- 申请人: Jean-Damien Charrier , Pierre-Henri Storck , John Studley , Francoise Yvonne Theodora Marie Pierard , Steven John Durrant , Benjamin Joseph Littler , Paul Angell , Robert Michael Hughes , David Andrew Siesel , Armando Urbina , Carl Zwicker , Nicholas LoConte , Timothy Barder
- 申请人地址: US MA Cambridge
- 专利权人: VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人: VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址: US MA Cambridge
- 主分类号: C07D413/14
- IPC分类号: C07D413/14 ; A61K45/06 ; A61N5/10 ; A61K31/4745 ; A61K31/7068 ; A61K31/497 ; A61K33/24
摘要:
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I-1: wherein the variables are as defined herein.Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.
公开/授权文献
- US08846686B2 Compounds useful as inhibitors of ATR kinase 公开/授权日:2014-09-30
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