发明申请
- 专利标题: COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
- 专利标题(中): 化合物作为ATR激酶的抑制剂有用
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申请号: US13440981申请日: 2012-09-04
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公开(公告)号: US20130095193A1公开(公告)日: 2013-04-18
- 发明人: Jean-Damien Charrier , David Kay , Somhairle MacCormick , Pierre-Henri Storck , Joanne Pinder , Michael Edward O'Donnell , Ronald Marcellus Alphonsus Knegtel , Stephen Clinton Young , Philip Michael Reaper , Steven John Durrant , Heather Clare Twin , Christopher John Davis
- 申请人: Jean-Damien Charrier , Somhairle MacCormick , Pierre-Henri Storck , Joanne Pinder , Michael Edward O'Donnell , Ronald Marcellus Alphonsus Knegtel , Stephen Clinton Young , Philip Michael Reaper , Steven John Durrant , Heather Clare Twin , Christopher John Davis
- 申请人地址: US MA Cambridge
- 专利权人: VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人: VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址: US MA Cambridge
- 主分类号: C07D413/14
- IPC分类号: C07D413/14 ; A61K31/5377 ; C07D453/00 ; C07D495/04 ; A61K31/7068 ; A61K45/06 ; A61K31/501 ; A61K31/55 ; A61K31/7048 ; A61K31/497 ; A61K33/24
摘要:
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
公开/授权文献
- US08877759B2 Aminopyrazines as ATR kinase inhibitors 公开/授权日:2014-11-04