发明申请
US20130102603A1 2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER
有权
2,4-DIARYL - 取代[1,8]萘啶类作为激酶使用抗癌剂
![2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER](/docs/US/2013-04-25/US20130102603A1/abs.jpg.600x600.jpg)
- 专利标题： 2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER
- 专利标题（中）： 2,4-DIARYL - 取代[1,8]萘啶类作为激酶使用抗癌剂
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申请号： US13807119申请日： 2011-05-31
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公开(公告)号： US20130102603A1公开(公告)日： 2013-04-25
- 发明人: Dieter Dorsch , Alfred Jonczyk , Guenter Hoelzemann , Christiane Amendt , Frank Zenke
- 申请人： Dieter Dorsch , Alfred Jonczyk , Guenter Hoelzemann , Christiane Amendt , Frank Zenke
- 申请人地址： DE Darmstadt
- 专利权人： MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
- 当前专利权人： MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
- 当前专利权人地址： DE Darmstadt
- 优先权： EP10006683.6 20100628
- 国际申请： PCT/EP2011/002692 WO 20110531
- 主分类号： C07D491/048
- IPC分类号： C07D491/048 ; A61K31/5377 ; A61K31/517 ; A61K31/519 ; C07D471/04 ; A61K31/4375
![2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER](/abs-image/US/2013/04/25/US20130102603A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
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