发明申请
- 专利标题： CREATION OF OXIDATION-RESISTANT HDL MIMETIC PEPTIDES
- 专利标题（中）： 抗氧化高密度脂蛋白胶原蛋白的产生
-
申请号： US13643935申请日： 2011-04-28
-
公开(公告)号： US20130123173A1公开(公告)日： 2013-05-16
- 发明人: John K. Bielicki , Jan Johansson
- 申请人： John K. Bielicki , Jan Johansson
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 国际申请： PCT/US11/34279 WO 20110428
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; A61K38/16
摘要：
The present invention provides non-naturally occurring polypeptides that are oxidation resistant and have cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABACI that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation; and diagnostic methods employing the peptides to evaluated cholesterol efflux activity.
信息查询
