发明申请
- 专利标题： TEMPERATURE RESPONSIVE SHEET THAT DISPLAYS REVERSIBLE PROPERTIES AND CELL SHEET PRODUCTION METHOD USING SAME
- 专利标题（中）： 显示可逆性的温度响应表和使用相同的细胞片生产方法
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申请号： US13703318申请日： 2011-06-09
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公开(公告)号： US20130130384A1公开(公告)日： 2013-05-23
- 发明人: Kouji Okamoto , Erika Yoshino
- 申请人： Kouji Okamoto , Erika Yoshino
- 申请人地址： JP Kitakyushu-shi, Fukuoka
- 专利权人： KYUSHU INSTITUTE OF TECHNOLOGY
- 当前专利权人： KYUSHU INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： JP Kitakyushu-shi, Fukuoka
- 优先权： JP2010-132976 20100610
- 国际申请： PCT/JP2011/063265 WO 20110609
- 主分类号： C12N5/00
- IPC分类号： C12N5/00
摘要：
A temperature responsive sheet is disclosed that comprises a chemically modified water-soluble elastin obtained by N-acylating at least some of the primary amines and secondary amines contained in a high molecular weight water-soluble elastin molecule and coupling some or all of carboxyl groups contained in the molecule with a glycine alkyl ester. Also is disclosed a process for producing a cell sheet that comprises preparing above the temperature responsive sheet a film that functions as a scaffold for animal cells, culturing specific cells on the film so as to prepare a cell sheet, and subsequently separating the cell sheet and the temperature responsive sheet comprising the chemically modified water-soluble elastin under conditions of no greater than the culturing temperature for the cells.
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