发明申请
- 专利标题： DETECTION METHOD OF NOVEL RET FUSION
- 专利标题（中）： 新型RET融合检测方法
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申请号： US13812356申请日： 2011-07-22
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公开(公告)号： US20130137111A1公开(公告)日： 2013-05-30
- 发明人: Nobuaki Shindo , Kouichi Nishimura , Yorikata Sano , Makoto Asaumi , Aya Yamanaka , Takashi Futami , Tatsuya Kawase
- 申请人： Nobuaki Shindo , Kouichi Nishimura , Yorikata Sano , Makoto Asaumi , Aya Yamanaka , Takashi Futami , Tatsuya Kawase
- 申请人地址： JP Tokyo
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： JP Tokyo
- 优先权： JP2010-166674 20100726
- 国际申请： PCT/JP11/66661 WO 20110722
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
It was found that a new fusion gene of a portion of the KIF5B gene and a portion of the RET gene, which is present in a portion of cancer patients, is a gene responsible for cancer. Based on this finding, detection methods of a polynucleotide as the gene and a polypeptide encoded by the polynucleotide were established. The detection methods involve detecting a fusion gene of a portion of the KIF5B gene and a portion of the RET gene, or a fusion protein encoded by such a fusion gene. The primer sets and the detection kits comprise sense primers designed from a portion encoding KIF5B and antisense primers designed from a portion encoding RET.
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