公开(公告)号：US09267176B2

公开(公告)日：2016-02-23

申请号：US14236993

申请日：2012-08-03

申请人： Takashi Futami ,  Tatsuya Kawase ,  Nobuaki Shindou ,  Rumi Takeshita

发明人： Takashi Futami ,  Tatsuya Kawase ,  Nobuaki Shindou ,  Rumi Takeshita

IPC分类号： G01N33/53 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： [Problem] An object of the present invention is to elucidate a novel genetic mutation which is a cause of cancer, and thereby, to provide a method for detecting the genetic mutation, or a protein which has the mutation, a method for detecting the presence of cancer in a subject, a method for diagnosing cancer in a subject, and a primer set, a probe and a detecting kit for the methods.[Means for Solution] A method for detecting a fibroblast growth factor receptor 4 (FGFR4) mutant in a subject, which comprises a step of detecting the presence of the mutation of glycine at position 183 in a FGFR4 tyrosine kinase domain to cysteine in a sample obtained from the subject.

摘要翻译： 本发明的目的是阐明作为癌症的原因的新型遗传突变，从而提供检测遗传突变的方法或具有突变的蛋白质，检测存在的方法 受试者中的癌症，用于诊断受试者中的癌症的方法，以及用于该方法的引物组，探针和检测试剂盒。 [解决方案]一种检测受试者中成纤维细胞生长因子受体4（FGFR4）突变体的方法，其包括检测在FGFR4酪氨酸激酶结构域中的位置183处的甘氨酸突变存在于样品中的半胱氨酸的步骤 从主题获得。

公开(公告)号：US09255817B2

公开(公告)日：2016-02-09

申请号：US14279637

申请日：2014-05-16

申请人： Tatsuya Kawase

发明人： Tatsuya Kawase

IPC分类号： G01B7/00 ,  G01R33/022 ,  G01D5/14 ,  G01D5/244

CPC分类号： G01D5/145 ,  G01D5/2448

摘要： A rotation-angle detection device includes: an amplitude adjustment unit that performs correction to match amplitude values of multiple detection signals output from multiple rotation detection units to output corrected signals, the rotation detection units changing outputs in accordance with a rotation angle of a rotor and being provided such that the rotation detection units output the detection signals having different phases; a vector generation unit that performs addition and subtraction on two signals out of the corrected signals to generate two vector component signals that are perpendicular to each other; an amplitude correction unit that performs correction to match amplitudes of the two vector component signals to output corrected vector component signals; and a rotation-angle searching unit that searches for the rotation angle of the rotor on basis of a vector that is represented by the two corrected vector component signals to output a detection angle.

摘要翻译： 旋转角度检测装置包括：振幅调整单元，其执行校正，以匹配从多个旋转检测单元输出的多个检测信号的振幅值，以输出校正信号，所述旋转检测单元根据转子的旋转角度改变输出， 被设置为使得旋转检测单元输出具有不同相位的检测信号; 矢量生成单元，对经校正的信号进行两个信号的加减运算，生成彼此垂直的两个矢量分量信号; 幅度校正单元，执行校正以匹配两个矢量分量信号的幅度以输出校正的矢量分量信号; 以及旋转角搜索单元，其基于由两个校正矢量分量信号表示的矢量来搜索转子的旋转角度，以输出检测角度。

公开(公告)号：US20140220035A1

公开(公告)日：2014-08-07

申请号：US14236993

申请日：2012-08-03

申请人： Takashi Futami ,  Tatsuya Kawase ,  Nobuaki Shindou ,  Rumi Takeshita

发明人： Takashi Futami ,  Tatsuya Kawase ,  Nobuaki Shindou ,  Rumi Takeshita

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： [Problem] An object of the present invention is to elucidate a novel genetic mutation which is a cause of cancer, and thereby, to provide a method for detecting the genetic mutation, or a protein which has the mutation, a method for detecting the presence of cancer in a subject, a method for diagnosing cancer in a subject, and a primer set, a probe and a detecting kit for the methods.[Means for Solution] A method for detecting a fibroblast growth factor receptor 4 (FGFR4) mutant in a subject, which comprises a step of detecting the presence of the mutation of glycine at position 183 in a FGFR4 tyrosine kinase domain to cysteine in a sample obtained from the subject.

摘要翻译： 本发明的目的是阐明作为癌症的原因的新型遗传突变，从而提供检测遗传突变的方法或具有突变的蛋白质，检测存在的方法 受试者中的癌症，用于诊断受试者中的癌症的方法，以及用于该方法的引物组，探针和检测试剂盒。 [解决方案]一种检测受试者中成纤维细胞生长因子受体4（FGFR4）突变体的方法，其包括检测在FGFR4酪氨酸激酶结构域中的位置183处的甘氨酸突变存在于样品中的半胱氨酸的步骤 从主题获得。

公开(公告)号：US09903740B2

公开(公告)日：2018-02-27

申请号：US14554201

申请日：2014-11-26

申请人： Hirofumi Nishi ,  Tatsuya Kawase

发明人： Hirofumi Nishi ,  Tatsuya Kawase

IPC分类号： G01D5/245 ,  G06K9/52 ,  G06T1/00

CPC分类号： G01D5/2451 ,  G06K9/52 ,  G06T1/00

摘要： A rotation-angle detecting device includes: an angle detecting unit that detects a rotation angle of a rotating body on the basis of sinusoidal wave signals that multiple sensors arranged to have a phase difference output according to the rotation angle of the rotating body; and a resolution setting unit that allows change of a resolution of the rotation angle detected by the angle detecting unit.

公开(公告)号：US20140354271A1

公开(公告)日：2014-12-04

申请号：US14278069

申请日：2014-05-15

申请人： Tatsuya KAWASE

发明人： Tatsuya KAWASE

IPC分类号： G01D5/14

CPC分类号： G01D5/2451

摘要： Provided are a rotation angle detector and a rotation angle detecting method. Each of the rotation angle detector and rotation angle detecting method detects a rotation angle of a rotating body according to a plurality of detection signals that vary depending on the rotation angle of the rotating body and have phases different from each other, to output the detected rotation angle as a detection angle, generates pseudo harmonics based on a multiplied detection angle obtained by multiplying the detection signal by a specified number, and removes the pseudo harmonics from the detection signals, to output a corrected detection signals from which the pseudo harmonics are removed to the detecting of the rotation angle, the detection angle being generated based on the correction detection signals.

摘要翻译： 提供旋转角度检测器和旋转角度检测方法。 旋转角度检测器和旋转角度检测方法中的每一个根据根据旋转体的旋转角度而变化的多个检测信号来检测旋转体的旋转角度，并且具有彼此不同的相位，以输出检测到的旋转 作为检测角度产生基于通过将检测信号乘以规定数目而获得的相乘检测角度的伪谐波，并且从检测信号中去除伪谐波，以将修正的检测信号从其中去除伪谐波被去除 检测旋转角度，检测角度是根据校正检测信号产生的。

公开(公告)号：US20140347040A1

公开(公告)日：2014-11-27

申请号：US14279637

申请日：2014-05-16

申请人： Tatsuya KAWASE

发明人： Tatsuya KAWASE

IPC分类号： G01D5/14 ,  G01D18/00

CPC分类号： G01D5/145 ,  G01D5/2448

摘要： A rotation-angle detection device includes: an amplitude adjustment unit that performs correction to match amplitude values of multiple detection signals output from multiple rotation detection units to output corrected signals, the rotation detection units changing outputs in accordance with a rotation angle of a rotor and being provided such that the rotation detection units output the detection signals having different phases; a vector generation unit that performs addition and subtraction on two signals out of the corrected signals to generate two vector component signals that are perpendicular to each other; an amplitude correction unit that performs correction to match amplitudes of the two vector component signals to output corrected vector component signals; and a rotation-angle searching unit that searches for the rotation angle of the rotor on basis of a vector that is represented by the two corrected vector component signals to output a detection angle.

摘要翻译： 旋转角度检测装置包括：振幅调整单元，其执行校正，以匹配从多个旋转检测单元输出的多个检测信号的振幅值，以输出校正信号，所述旋转检测单元根据转子的旋转角度改变输出， 被设置为使得旋转检测单元输出具有不同相位的检测信号; 矢量生成单元，对经校正的信号进行两个信号的加减运算，生成彼此垂直的两个矢量分量信号; 幅度校正单元，执行校正以匹配两个矢量分量信号的幅度以输出校正的矢量分量信号; 以及旋转角搜索单元，其基于由两个校正矢量分量信号表示的矢量来搜索转子的旋转角度，以输出检测角度。

公开(公告)号：US09435664B2

公开(公告)日：2016-09-06

申请号：US14278069

申请日：2014-05-15

申请人： Tatsuya Kawase

发明人： Tatsuya Kawase

IPC分类号： G01B7/30 ,  G01D5/245

CPC分类号： G01D5/2451

摘要： Provided are a rotation angle detector and a rotation angle detecting method. Each of the rotation angle detector and rotation angle detecting method detects a rotation angle of a rotating body according to a plurality of detection signals that vary depending on the rotation angle of the rotating body and have phases different from each other, to output the detected rotation angle as a detection angle, generates pseudo harmonics based on a multiplied detection angle obtained by multiplying the detection signal by a specified number, and removes the pseudo harmonics from the detection signals, to output a corrected detection signals from which the pseudo harmonics are removed to the detecting of the rotation angle, the detection angle being generated based on the correction detection signals.

摘要翻译： 提供旋转角度检测器和旋转角度检测方法。 旋转角度检测器和旋转角度检测方法中的每一个根据根据旋转体的旋转角度而变化的多个检测信号来检测旋转体的旋转角度，并且具有彼此不同的相位，以输出检测到的旋转 作为检测角度产生基于通过将检测信号乘以规定数目而获得的相乘检测角度的伪谐波，并且从检测信号中去除伪谐波，以将修正的检测信号从其中去除伪谐波被去除 检测旋转角度，检测角度是根据校正检测信号产生的。

公开(公告)号：US20150153154A1

公开(公告)日：2015-06-04

申请号：US14554201

申请日：2014-11-26

申请人： Hirofumi Nishi ,  Tatsuya Kawase

发明人： Hirofumi Nishi ,  Tatsuya Kawase

IPC分类号： G01B7/30 ,  G06K9/52 ,  G06T1/00 ,  G01B7/00

CPC分类号： G01D5/2451 ,  G06K9/52 ,  G06T1/00

摘要： A rotation-angle detecting device includes: an angle detecting unit that detects a rotation angle of a rotating body on the basis of sinusoidal wave signals that multiple sensors arranged to have a phase difference output according to the rotation angle of the rotating body; and a resolution setting unit that allows change of a resolution of the rotation angle detected by the angle detecting unit.

摘要翻译： 旋转角度检测装置包括：角度检测单元，其基于正弦波信号检测旋转体的旋转角度，多个传感器被布置成根据旋转体的旋转角度输出相位差; 以及分辨率设定单元，其允许改变由角度检测单元检测到的旋转角度的分辨率。

公开(公告)号：US09742425B2

公开(公告)日：2017-08-22

申请号：US14682194

申请日：2015-04-09

申请人： Tatsuya Kawase

发明人： Tatsuya Kawase

IPC分类号： G01B7/30 ,  H03M1/66 ,  G01D5/14 ,  G01D5/244 ,  H03M1/30

CPC分类号： H03M1/668 ,  G01D5/145 ,  G01D5/24471 ,  H03M1/303

摘要： A rotation detector detecting rotation of a rotor, based on a signal produced according to rotation of the rotor, having a waveform according to a rotational cycle thereof, includes a signal obtaining unit to obtain two signals having phases different from each other; a vector operating unit to determine a vector according to a rotational angle of the rotor, based on the two signals; and a rotation detecting unit to detect rotation of the rotor, based on the vector. The two signals are produced from two elements located at positions farthest in a rotational angle of the rotor among plural rotation detecting elements located at positions different from each other.

公开(公告)号：US20150292907A1

公开(公告)日：2015-10-15

申请号：US14682194

申请日：2015-04-09

申请人： Tatsuya KAWASE

发明人： Tatsuya KAWASE

IPC分类号： G01D5/14 ,  H03M1/66 ,  H02K11/00

CPC分类号： H03M1/668 ,  G01D5/145 ,  G01D5/24471 ,  H03M1/303

摘要： A rotation detector detecting rotation of a rotor, based on a signal produced according to rotation of the rotor, having a waveform according to a rotational cycle thereof, includes a signal obtaining unit to obtain two signals having phases different from each other; a vector operating unit to determine a vector according to a rotational angle of the rotor, based on the two signals; and a rotation detecting unit to detect rotation of the rotor, based on the vector. The two signals are produced from two elements located at positions farthest in a rotational angle of the rotor among plural rotation detecting elements located at positions different from each other.

摘要翻译： 基于根据转子的旋转产生的具有根据其旋转周期的波形产生的信号的旋转检测器的旋转检测器包括：信号获取单元，用于获得具有彼此不同的相位的两个信号; 矢量操作单元，基于所述两个信号来确定根据所述转子的旋转角度的向量; 以及基于矢量检测转子的旋转的旋转检测单元。 两个信号由位于彼此不同的位置的多个旋转检测元件中位于转子旋转角度最远的位置的两个元件产生。