Disclosed are various embodiments providing adaptive path selection for interference cancellation for wireless communication devices. Signal strength metrics are obtained for each of multiple signal paths. One or more of the signal paths are selected as cancellation candidates in response to determining that the signal paths are associated with a strong interfering path based at least in part on the signal strength metrics for the signal paths and threshold criteria. Cancellation is enabled for an estimated signal generated using the signal paths in response to the signal paths being selected as cancellation candidates.