发明申请
- 专利标题： Translation Kinetic Mapping, Modification and Harmonization
- 专利标题（中）： 翻译动力学映射，修改与协调
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申请号： US13664252申请日： 2012-10-30
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公开(公告)号： US20130149699A1公开(公告)日： 2013-06-13
- 发明人: Jose M. Barral , Andrew Fire , Paige S. Spencer , Michael Stadler
- 申请人： The Board of Trustees of the Leland Stanford Junio , The University of Texas Medical Branch at Galvest
- 申请人地址： US TX Galveston US CA Palo Alto
- 专利权人： The University of Texas Medical Branch at Galveston,The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The University of Texas Medical Branch at Galveston,The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US TX Galveston US CA Palo Alto
- 主分类号： C07H21/02
- IPC分类号： C07H21/02
摘要：
The profile of translation elongation rate along an mRNA is modulated in a directed manner by locally altering codon usage, in particular utilizing differences in ribosomal dwell times among pairs of synonymous codons translated by a single tRNA through wobble base pairing. Unlike codon optimization based on organism-specific codon frequencies or tRNA pools, the methods of the invention need not change the tRNA that translates the codon, rather modulating the interaction between a given tRNA and the mRNA coding sequence.
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