This disclosure describes systems and methods for piloting a pneumatic valve using one or more piezoelectric blowers. According to embodiments, the one or more piezoelectric blowers may be coupled to the pneumatic valve to form a small, light-weight pneumatic valve that may be placed proximal to a ventilated patient, e.g., at the patient wye or the patient interface. Due to the close coupling of the one or more piezoelectric blowers, the pneumatic valve has a substantially shorter response time than traditional pneumatically piloted valves. Moreover, when piezoelectric blowers are coupled to the pneumatic valve in parallel, response time may be further decreased. Additionally or alternatively, when piezoelectric blowers are coupled to the pneumatic valve in series, pilot pressure may be increased as a function of the number of piezoelectric blowers in the series.