A cooperative diagnostic and prognosis system for generating a prognosis of at least one component in a vehicle. An in-vehicle diagnostic unit determines a diagnostic signature of the component each time an occurrence of a condition is triggered and transmits the diagnostic signature to an off-board diagnostic unit. The off-vehicle diagnostic unit determines a SOH of the component and a rate-of-change in the SOH of the component. The off-vehicle diagnostic unit determines whether the rate-of-change in the SOH is greater than a threshold. The off-vehicle diagnostic unit requests additional information from the vehicle in response to the rate-of-change in the SOH being greater than the threshold. The additional information relating to operating parameter data associated with the component. The off-vehicle diagnostic unit receives the requested information and predicts a time-to-failure of the component.