发明申请
- 专利标题： METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION
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申请号： US13750092申请日： 2013-01-25
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公开(公告)号： US20130195895A1公开(公告)日： 2013-08-01
- 发明人: Vijay K. Kuchroo , Sumone Chakravarti , Terry Strom , Xin Xiao Zheng , Jennifer Meyers
- 申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
- 申请人地址： US MA Boston US MA Boston
- 专利权人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC.,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 当前专利权人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC.,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- 当前专利权人地址： US MA Boston US MA Boston
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K38/17
摘要：
The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.
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