公开(公告)号：US20150079085A1

公开(公告)日：2015-03-19

申请号：US14503768

申请日：2014-10-01

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

发明人： Vijay K. Kuchroo ,  Sumone Chakravarti ,  Terry Strom ,  Xin Xiao Zheng ,  Jennifer Meyers

IPC分类号： C07K16/28 ,  C07K14/705

CPC分类号： C07K16/2803 ,  A61K38/00 ,  A61K38/177 ,  A61K39/39541 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/70503 ,  C07K16/2875 ,  C07K2319/00 ,  C12N2310/14 ,  G01N33/5768 ,  G01N33/6812 ,  G01N33/6845 ,  G01N33/6863 ,  G01N33/6872 ,  G01N2500/02 ,  G01N2800/24 ,  A61K2300/00

摘要： The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.

摘要翻译： 本发明涉及调节受试者的免疫应答的方法，例如通过施用调节tim-1，tim-2或tim-4活性或调节tim-1和tim-4之间的物理相互作用的受试者，或 在tim-2和tim-2配体之间。 免疫反应包括但不限于自身免疫性疾病，移植耐受性和Th1和Th2介导的应答和障碍。 本发明还涉及用于鉴定调节tim-1和tim-4之间的物理相互作用的试剂的新型测定法。 此外，本发明涉及新的可溶性tim-4多肽和编码它们的核酸。

公开(公告)号：US20130195895A1

公开(公告)日：2013-08-01

申请号：US13750092

申请日：2013-01-25

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

发明人： Vijay K. Kuchroo ,  Sumone Chakravarti ,  Terry Strom ,  Xin Xiao Zheng ,  Jennifer Meyers

IPC分类号： A61K39/395 ,  A61K38/17

CPC分类号： C07K16/2803 ,  A61K38/00 ,  A61K38/177 ,  A61K39/39541 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/70503 ,  C07K16/2875 ,  C07K2319/00 ,  C12N2310/14 ,  G01N33/5768 ,  G01N33/6812 ,  G01N33/6845 ,  G01N33/6863 ,  G01N33/6872 ,  G01N2500/02 ,  G01N2800/24 ,  A61K2300/00

摘要： The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.