发明申请
US20130196342A1 Compositions And Methods For Modulating S-Nitrosogluthione Reductase
审中-公开
用于调节S-硝基葡萄糖还原酶的组合物和方法
- 专利标题： Compositions And Methods For Modulating S-Nitrosogluthione Reductase
- 专利标题（中）： 用于调节S-硝基葡萄糖还原酶的组合物和方法
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申请号： US13094091申请日： 2011-04-26
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公开(公告)号： US20130196342A1公开(公告)日： 2013-08-01
- 发明人: Jonathan S. Stamler , Limin Liu
- 申请人： Jonathan S. Stamler , Limin Liu
- 申请人地址： US NC Durham
- 专利权人： Duke University
- 当前专利权人： Duke University
- 当前专利权人地址： US NC Durham
- 主分类号： G01N33/573
- IPC分类号： G01N33/573
摘要：
Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
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