发明申请
- 专利标题： METHOD OF PREPARING TETRABENAZINE AND DIHYDROTETRABENAZINE
- 专利标题（中）： 制备四氢萘啶酮和二氢吗啡酮的方法
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申请号： US13617357申请日： 2012-09-14
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公开(公告)号： US20130197227A1公开(公告)日： 2013-08-01
- 发明人: Sun Joon MIN , Yong Seo Cho , Jae Kyun Lee , Ae Nim Pae , Young Wook Son
- 申请人： Sun Joon MIN , Yong Seo Cho , Jae Kyun Lee , Ae Nim Pae , Young Wook Son
- 申请人地址： KR Seoul
- 专利权人： Korea Institute of Science and Technology
- 当前专利权人： Korea Institute of Science and Technology
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2012-0009756 20120131
- 主分类号： C07D455/06
- IPC分类号： C07D455/06 ; C07F7/10
摘要：
The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an Aza-Prins cyclization reaction in the presence of an oxidant and an oxidation reaction.
公开/授权文献
- US08993766B2 Method of preparing tetrabenazine and dihydrotetrabenazine 公开/授权日：2015-03-31
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